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KMID : 0605620150220020034
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Journal of Korean Society of Biological Psychiatry
2015 Volume.22 No. 2 p.34 ~ p.39
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Neuroglia and Mood Disorder
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Lee Jung-Goo
Seo Mi-Kyoung
Park Sung-Woo
Kim Young-Hoon
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Abstract
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Mood disorder is a common psychiatric illness with a high lifetime prevalence in the general population. A serious problem such as suicide is commonly occurring in the patients with depression. Till now, the monoamine hypothesis has been the most popular theory of pathogenesis for depression. However, the more specific pathophysiology of depression and cellular molecular mechanism underlying action of commercial antidepressants have not been clearly defined. Several recent studies demonstrated that glial cells, especially astrocytes, are a promising answer to the pathophysiology of depression. In this article, current understanding of biology and molecular mechanisms of glial cells in the pathology of mood disorder and new research on the pathophysiology of depression will be discussed.
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KEYWORD
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Mood disorder, Glial cell, Astrocyte, Pathophysiology, Antidepressants
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